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Ribociclib

Chemical Name:LEE011
CAS No.: 1256963-02-6
Molecular formula: C22H29ClN8
Molecular weight: 440.97226
...

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Related Categories: Small molecule inhibitors; small molecule inhibitors, natural products; pharmaceutical raw materials; Inhibitors

1256963-02-6

Indication

Rebizzini is indicated for use in combination with aromatase inhibitors as an initial endocrine therapy for the treatment of postmenopausal hormone receptor HR+ positive, HER2 advanced or metastatic breast cancer.


Function

Rebizzini is a cyclin-dependent kinases 4/6 (CDK4/6) inhibitor that binds to the cell D-cyclin to form an activity. After the complex, it plays a key role in signaling pathways that regulate cell cycle progression and cell proliferation.


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