Products Categories
Contact Us
  • ADDRESS:Room 102, Unit 3, Building 17, Puya Ziyu Road, Ganjingzi District, Dalian City, Liaoning Province, China
  • E-MAIL:
    dlsky@dlskychem.com
  • TEL:+86-411-86487833

Regorafenib

CAS No.: 755037-03-7
Molecular formula: C21H15ClF4N4O3
Molecular weight: 482.8154128
...

Send Inquiry

755037-03-7


Nature

Melting point

206.0 to 210.0 °C


Synthetic route

Method 1:4-chloro-2-pyridine formamide hydrochloride was prepared from 2-pyridine formic acid by chlorination and amidation. Rigofini was prepared from 4-amino-3-fluorophenol and 4-chloro-3-trifluoromethyl benzene isocyanate in a pot. The specific reaction process was as follows:

image002

Method 2:2 - piperidine formic acid as raw material, through chlorination, amidation, methanol solution by 4 - chloro - 2 - pyridine formamide, and amino - 4-3 - p -fluorophenol nucleophilic replace get 4 - (4 - amino - 3-3 methyl) - N - methyl pyridine - 2 - formamide, and again three fluorine chlorine - 4-3 - methyl phenyl isocyanate condensation Craig fini, get specific reaction process is as follows:

image003


Hot Tags: regorafenib, manufacturers, suppliers, factory, wholesale, buy, quotation, low price, free sample
Related Products
  • Dalian Sky Chemical Co.,Ltd
    • ADDRESS:Room 102, Unit 3, Building 17, Puya Ziyu Road, Ganjingzi District, Dalian City, Liaoning Province, China
    • E-MAIL:
      dlsky@dlskychem.com
    • TEL:+86-411-86487833
  • TRY BEST! TO BE NO.1

    After 26 years business done, we have excellent knowledge in the Chinese market. We provide the best price/quality ratio to satisfy requirements of global market.

  • QR CODE