Related categories: APIs; biochemical reagents; microbial metabolites; pharmaceutical intermediates; antibiotics; fermentation; raw materials; small molecule inhibitors, natural products;
D21 -35° (c = 0.7 in methanol)
Store at -20°C
(-)-Epothilone B is a stable drug of microtubule (MT) derived from the natural mucobacteria Sorangium cellulosum, which is a macrolide antitumor factor. EpoB is similar to EpoA in its biological properties. However, in potent anti-P-glycoprotein expression multidrug resistance (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells), EpoB was 10 times more potent than EpoA. (-)-Epothilone B is similar to paclitaxel and is an alternative to paclitaxel in cell growth. EpoB causes cell cycle arrest (IC50 = 3.5 nM).