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Patupilone

​CAS No.: 152044-54-7
Molecular formula: C27H41NO6S
Molecular weight: 507.68
...

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Related categories: APIs; biochemical reagents; microbial metabolites; pharmaceutical intermediates; antibiotics; fermentation; raw materials; small molecule inhibitors, natural products;

152044-54-7


Nature

Melting point

95-97°C

Specific rotation

D21 -35° (c = 0.7 in methanol)

Density

1.136

Storage conditions

Store at -20°C

colour

colorless

InChIKey

QXRSDHAAWVKZLJ-PVYNADRNSA-N

CAS database

152044-54-7


Use

(-)-Epothilone B is a stable drug of microtubule (MT) derived from the natural mucobacteria Sorangium cellulosum, which is a macrolide antitumor factor. EpoB is similar to EpoA in its biological properties. However, in potent anti-P-glycoprotein expression multidrug resistance (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells), EpoB was 10 times more potent than EpoA. (-)-Epothilone B is similar to paclitaxel and is an alternative to paclitaxel in cell growth. EpoB causes cell cycle arrest (IC50 = 3.5 nM).


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