Products Categories
Contact Us
  • ADDRESS:Room 102, Unit 3, Building 17, Puya Ziyu Road, Ganjingzi District, Dalian City, Liaoning Province, China
  • E-MAIL:
    dlsky@dlskychem.com
  • TEL:+86-411-86487833

Eperisone Hydrochloride

CAS No.: 56839-43-1
Molecular formula: C17H26ClNO
Molecular weight: 295.85
Related categories: pharmaceutical intermediates; intermediates; pharmaceutical raw materials; organic raw materials;
...

Send Inquiry

image002

Nature

Melting point

169-171°C

Storage conditions

-20°C Freezer

CAS database

56839-43-1(CAS DataBase Reference)


Preparation

The product was synthesized by reacting p-ethylpropiophenone (2) with guanidine hydrochloride through Mannieh. The route is shown in Figure 1:
image003

Figure 1 shows the reaction route for the synthesis of eperisone hydrochloride

resolve resolution:

1. Synthesis of p-ethylpropiophenone (2)

Propylene chloride (100 g, 1.08 mol) was charged, and the treated reaction liquid was recovered to recover petroleum ether and excess ethylbenzene, and then distilled under reduced pressure to collect bP112-114 ° C / 1.33 kPa fraction to obtain 2.
2. Synthesis of acetaminophen hydrochloride (1)

Take a new distillation and stir (20.2g, 0.24 mol), add absolute ethanol (20 ml), add concentrated hydrochloric acid to pH 4-5 at low temperature, distill off ethanol under reduced pressure and then add absolute ethanol (50 ml). p-Ethylpropiophenone (32.4g, 0.2mol), 36% formaldehyde solution (42.0g, 0.5mol) and concentrated hydrochloric acid (1ml), stirred under reflux for 8h, the solvent was evaporated, the residue was dissolved in 10% sodium hydroxide, ether The extract is washed with water, dried, and hydrogen chloride is introduced into the ice water bath to pH 2-3. The resulting solid was filtered off and recrystallized from ethanol-hexane to give 1 colorless crystal.


Hot Tags: eperisone hydrochloride, manufacturers, suppliers, factory, wholesale, buy, quotation, low price, free sample
Related Products
  • Dalian Sky Chemical Co.,Ltd
    • ADDRESS:Room 102, Unit 3, Building 17, Puya Ziyu Road, Ganjingzi District, Dalian City, Liaoning Province, China
    • E-MAIL:
      dlsky@dlskychem.com
    • TEL:+86-411-86487833
  • TRY BEST! TO BE NO.1

    After 26 years business done, we have excellent knowledge in the Chinese market. We provide the best price/quality ratio to satisfy requirements of global market.

  • QR CODE