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D-Timolol Maleate

CAS No.: 26839-77-0
Molecular formula: C17H28N4O7S
Molecular weight: 432.49182
Related Categories: Pharmaceutical Raw Materials; Timolol Maleate 26839-77-0 API
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26839-77-0

Structure and physical and chemical properties

Timolol maleate is a white crystalline powder, odorless and bitter. The temperature of 199-203 ° C, decomposition when molten. Dissolved in water or methanol, slightly soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether.


Indication

Timolol maleate is mainly used for primary open angle glaucoma, aphakic glaucoma, some secondary glaucoma and high intraocular pressure; it is also suitable for some glaucoma that is ineffective for medication or surgery.


Pharmacological action and mechanism of action

Timolol maleate is a beta-adrenergic blocker, glaucoma eye, 8 times the intensity of the use of Pu Cailuol, can reduce the formation of aqueous humor in the eye, and significantly reduce the effect of intraocular pressure. There was no significant endogenous sympathomimetic activity and no local anesthetic effect. Does not reduce the pupil, does not affect the visual acuity, does not cause ciliary muscle spasm, does not appear obvious blurred vision or night blindness. Twenty minutes after the eye drops, the intraocular pressure began to decrease, and the maximum decrease was achieved after 2 hours, and it was allowed to continue for 24 hours. Timolol maleate has a good effect on glaucoma, especially primary and open-angle glaucoma, and is superior to traditional hypotensive drugs. It is characterized by fast onset, small side effects and good tolerance. No effect on pupil size, response to light, and vision. For some patients, timolol maleate has an additive effect with some anti-glaucoma drugs. In addition, there is a certain effect on aphakic glaucoma, some secondary glaucoma, ocular hypertension and other glaucoma that are ineffective for drugs and surgery.


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