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Cisplatin

CAS No.: 15663-27-1
Molecular formula: Cl2H6N2Pt
Molecular weight: 300.05
...

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Related Categories: APIs; anti-tumor; pharmaceutical raw materials; anti-tumor; cell cycle non-specific drugs

15663-27-1

Nature

Melting point

340 °C (dec.)(lit.)

Density

3,7 g/cm3

Storage conditions

Store at RT

Solubility

Soluble in DMF. Insoluble in most common solvents

form

crystalline

colour

yellow

Water solubility

<0.1 g/100 mL at 19 ºC

Merck

14,2317

stability

Stable. Incompatible with oxidizing agents, aluminium, antioxidants.

CAS database

15663-27-1(CAS DataBase Reference)


Chemical properties

Orange or yellow crystalline powder. Melting point 268-272 ° C (decomposition). Slightly soluble in water, soluble in dimethylformamide. It can be gradually converted into trans and hydrolyzed in aqueous solution.


Use

The product binds to DNA, causing cross-linking, thereby disrupting DNA function and inhibiting cell mitosis, a cell-specific drug. The product has a wide anti-tumor spectrum and is used for head and neck squamous cell carcinoma, ovarian cancer, embryonic cell carcinoma, spermatogonia, lung cancer, thyroid cancer, lymphosarcoma and reticular cell sarcoma.


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