Related categories: APIs; APIs; digestive system medications; pharmaceutical raw materials; small molecule inhibitors; cell signaling and neurobiology;
1.2583 (rough estimate)
Slightly soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute mineral acids.
Acidity coefficient (pKa)
pKa 6.80 (Uncertain)
0.5 g/100 mL at 20 ºC
51481-61-9(CAS DataBase Reference)
White or off-white crystalline powder, odorless and bitter. Soluble in methanol or dilute hydrochloric acid, soluble in ethanol, slightly soluble in isopropanol, slightly soluble in water. The temperature of 141 ~ 143 ° C. The solubility in water at 37 ° C was 1.14%.
Histamine H2 receptor antagonist. It can inhibit gastric acid secretion caused by histamine stimulation, and can inhibit gastric acid secretion induced by food, pentagastrin, caffeine and insulin, and can also inhibit basic gastric acid secretion. For gastric and duodenal ulcers, digestive esophagitis, Zhuo-Ai syndrome.