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Cimetidine

CAS No.: 51481-61-9
Molecular formula: C10H16N6S
Molecular weight: 252.34
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Related categories: APIs; APIs; digestive system medications; pharmaceutical raw materials; small molecule inhibitors; cell signaling and neurobiology;

51481-61-9

Nature

Melting point

139-144°C

Density

1.2583 (rough estimate)

Refractive index

1.5700 (estimate)

Storage conditions

2-8°C

Solubility

Slightly soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute mineral acids.

Acidity coefficient (pKa)

pKa 6.80 (Uncertain)

Water solubility

0.5 g/100 mL at 20 ºC

Merck

14,2279

CAS database

51481-61-9(CAS DataBase Reference)


Chemical properties

White or off-white crystalline powder, odorless and bitter. Soluble in methanol or dilute hydrochloric acid, soluble in ethanol, slightly soluble in isopropanol, slightly soluble in water. The temperature of 141 ~ 143 ° C. The solubility in water at 37 ° C was 1.14%.


Use

Histamine H2 receptor antagonist. It can inhibit gastric acid secretion caused by histamine stimulation, and can inhibit gastric acid secretion induced by food, pentagastrin, caffeine and insulin, and can also inhibit basic gastric acid secretion. For gastric and duodenal ulcers, digestive esophagitis, Zhuo-Ai syndrome.


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