Many evidences support the role of limonene in cancer prevention and treatment. In vivo studies have found that limonene has chemopreventive effects on the initiation and promotion of cancer in a variety of cancer systems, including chemical carcinogens-induced breast, skin, liver, lung and precancerous cancer models in rodents.
It is possible to inhibit cholesterol synthesis by inhibiting the activity of HMG-CoA reductase, a rate-limiting enzyme that inhibits cholesterol synthesis. Gallbladder drainage with a mixture of 97% d-limonene can effectively dissolve cholesterol stones left over from patients with post-operative stones.
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