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Imipenem

CAS No.: 74431-23-5
Molecular formula: C10H12N2O3S
Molecular weight: 240.28
Related Categories: β-lactam antibiotics; antibiotics; drugs; ROXIT; small molecule inhibitors; pharmaceutical raw materials;
...

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74431-23-5

Chemical properties

Crystallized from water-ethanol. [α] D23 + 86.8 ° (C = 0.05, 0.1 mol/L, phosphate buffer, Ph = 7). pKal is about 3.2 and pKa2 is about 9.9. UV maximum absorption (water): 299 nm (ε 9680, 98% hydroxylamine extraction). Solubility (mg/m1): water 10, methanol 5, ethanol 0.2, acetone <0.1, dimethylformamide <0.1, dimethyl sulfoxide 0.3.


Uses

Carbapenem-based extended-spectrum β-lactam antibiotics, which are semi-synthetic derivatives of thimycin, have antibacterial spectrum and action similar to that of thimycin, but are more stable than thienamycin. It is not cross-resistant with other antibiotics, but is easily damaged by renal peptidase, so it is often used in combination with a renal peptidase inhibitor (such as cilastatin sodium). Stable to β-lactamase. For urinary tract infections, lower respiratory tract infections, intra-abdominal infections, skin and soft tissue infections, digestive system infections, osteomyelitis, prostatitis, bacteremia, etc.


Nature

Melting point

193-198°C

Boiling point

567℃

RTECS number

CL5446516

Flash point

>110°(230°F)

Storage conditions

-20°C Freezer

Solubility

H2O: >5mg/mL

Acidity coefficient (pKa)

pKa 3.2/9.9(H2O,t = 25) (Uncertain)

colour

white to beige

Water solubility

Soluble in water at 5mg/ml

CAS database

74431-23-5(CAS DataBase Reference)


Upstream and downstream product information

Tetrahydrofuran -> acetic acid -> N, N-dimethylformamide -> sodium nitrite -> ammonium chloride -> methyl iodide -> ammonium acetate -> 6-aminopenicillanic acid - ->Quartz Glass-->Aqueous Sodium Bisulfite-->Benzyl Ester-->Methyl Ester--> Mercury Mercury--> Vinylacetic Acid-->Buffer (pH=7.0)


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