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Dextran

​CAS No.: 9004-54-0
Molecular formula: C17H32O10
Molecular weight: 396.42998
Related categories: pharmaceutical intermediates;
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CAS No.: 9004-54-0

Molecular formula: C17H32O10

Molecular weight: 396.42998

Related categories: pharmaceutical intermediates;

9004-54-0

Chemical properties:

Iron dextran injection is a dark brown colloidal solution. The iron dextran solid is a dark brown amorphous powder. Odorless, miso. It is hygroscopic in the air. Soluble in water, the solution is a dark brown colloidal solution, pH 5.2-6.5, insoluble in organic solvents such as ethanol.

Iron dextran injection is a complex of iron and dextran. After intramuscular injection, part of the iron was phagocytosed by macrophages and transferred to fibroblasts, and the rest of the iron was slowly removed from the injection portion (50% removed at 72 h) and transferred to the plasma via lymph. It can still be found in the blood 3 weeks after the injection. The iron is mainly stored in the liver spleen reticulocyte endothelial cells and slowly released for hemoglobin synthesis. This absorption route is not controlled by the gastrointestinal tract, so the recovery of stored iron is faster and more complete. However, the rate of hemoglobin rise is still the same as that of the oral preparation, with an average of about 0.15 g per day. Effective for iron deficiency anemia.


Uses:

The medium molecular dextran is mainly used to increase plasma volume and maintain blood pressure, mainly anti-shock. It is suitable for supplementing blood volume and maintaining blood pressure when a large amount of blood is lost. Hemorrhagic such as burns, trauma, trauma, etc. and first aid caused by excessive blood loss. Low molecular dextran, mainly to improve microcirculation, to prevent or eliminate intravascular red blood cell aggregation and thrombosis. The action and use of small molecule dextran is similar to that of a low molecular dextran machine.


Nature:

Specific rotation

198 º

Refractive index

185 ° (C=6, H2O)

Storage conditions

2-8°C

Solubility

H2O: soluble50mg/mL, clear to very slightly hazy, colorless to faintly yellow

form

Solid

colour

White to slightly off-white

PH value

2 - 10

Water solubility

Soluble in water, dimethyl sulfoxide, ethylene glycol and glycerol.

Merck

14,2948

stability

Stable. Keep dry. Incompatible with strong oxidizing agents.

EPA chemical information

Dextran(9004-54-0)


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