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Cefoperazone

CAS No: 62893-19-0
Molecular formula: C25H27N9O8S2
Molecular weight: 645.67
Related Categories: β-lactam antibiotics; antibiotics; drugs; pharmaceutical intermediates; Inhibitors; small molecule inhibitors, natural products; pharmaceutical raw materials; organic raw materials;
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62893-19-0

Nature:

Melting point

169-171 C

Acidity coefficient (pKa)

pKa 2.6 (Uncertain)

Merck

14,1930

CAS database

62893-19-0(CAS DataBase Reference)


Indication

Cefoperazone is used for upper and lower respiratory tract, biliary tract, urinary tract, genitals, bone and joints, skin and soft tissue infections caused by sensitive bacteria, sepsis, meningitis, peritonitis, otitis media, gonorrhea, etc.


Chemical properties

White or off-white crystalline powder, odorless, slightly bitter. It is hygroscopic. Soluble in acetone or dimethyl sulfoxide, slightly soluble in methanol or ethanol, very slightly soluble in ethyl acetate or water. [α]D20-30°~-38° (30mg of this product is dissolved in 1ml from phosphate buffer solution (1mol/L potassium dihydrogen phosphate solution is diluted with 10mol/L potassium hydroxide solution to a Ph value of 6.0) and a solution of acetonitrile (90:10)). It is stable at Ph=4.0-7.0, slightly unstable in acidity, and very unstable in alkaline state. Melting point 169 171 ° C (hydrate).

Cefoperazone SC (diuHl): C25H26N9O8S2Na. [62893-20-3]. White or off-white crystalline powder, odorless, bitter. It is hygroscopic. Soluble in water, slightly soluble in methanol, very slightly soluble in ethanol, insoluble in ethyl acetate, chloroform, ether, acetone and n-hexane. Melting point 180 ° C (decomposition) [α] D20-15 ° ~ -25 ° (10 mg of this product is dissolved in 1 ml of water).


Use

The third-generation cephalosporin broad-spectrum antibiotics have a bactericidal effect on a variety of Gram-positive and Gram-negative bacteria, and are superior to other cephalosporins in Pseudomonas aeruginosa. They are stable to β-lactamase and must be injected. medicine. Clinically used to treat sepsis, respiratory infections, biliary infections, urinary tract infections, reproductive system infections, skin and soft tissue infections.


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